17 U.S. Code § 107 - Limitations on exclusive rights: Fair use
Notwithstanding the provisions of sections 106 and 106A, the fair use of a copyrighted work, including such use by reproduction in copies or phonorecords or by any other means specified by that section, for purposes such as criticism, comment, news reporting, teaching (including multiple copies for classroom use), scholarship, or research, is not an infringement of copyright. In determining whether the use made of a work in any particular case is a fair use the factors to be considered shall include—
(1) the purpose and character of the use, including whether such use is of a commercial nature or is for nonprofit educational purposes [all mirrored content falls under this clause, any ads present are mirrored from the original site, mirrored content earns me no revenue whatsoever];
(2) the nature of the copyrighted work [this is a unique resource for the mentally ill, and preservation of it can be argued to be incredibly important];
(3) the amount and substantiality of the portion used in relation to the copyrighted work as a whole; and
(4) the effect of the use upon the potential market for or value of the copyrighted work. [absolutely none whatsoever, as the original work no longer exists anywhere else (outside of whatever bits and pieces archive.org managed to capture) - the original site was intermittantly completely unavailable for a extended period of time before its SSL certificate expired (and was never renewed), and eventually the site went offline for good, then finally the DNS records were removed at some point prior to May 2018, so at this point it is well beyond the 'dead and rotting' stage]
The fact that a work is unpublished shall not itself bar a finding of fair use if such finding is made upon consideration of all the above factors.

This domain is not controlled by Jerod Poore, and I will NOT continue redirecting traffic from this domain to crazymeds.us [as I formerly did] while Jerod continues with his immature temper tantrum over adblock or continues to fail to maintain his site, fucking over his entire community and countless visitors in the process. [belated clarification: with specific regards to the adblock drama I was referring to Poore at one point replacing his entire site with a single page complaining about the amount of revenue lost to users with ad blocking active, which is something that I took extreme exception to because this affected ALL visitors to the site regardless of if or if not they were actually using ad blocking]
This mirror is unfortunately incomplete (and very slightly outdated), as /CrazyTalk/ was not included when I scraped the site (it was far too large to scrape given the site's extremely poor performance, my wish to avoid worsening the poor performance further, and other factors). If you're looking for a replacement forum, I suggest visiting https://www.crazyboards.org/forums/. There are issues with many of the mirrored pages, I am working on identifying and fixing them, but I do not have the time to address every single issue at this moment (although by now the majority of these issues have been resolved). Dynamic content is obviously completely broken (this is beyond my control), and the loss of /CrazyTalk/ is quite bad given how much good user-generated info was on there, but you have Jerod to "thank" for that. Maybe I'll bring it back online at some point, but it wouldn't be the same as before. For now, I suggest visiting CrazyBoards instead.
Note (Oct 9 2018): Infrequent additional updates regarding the status of this site will be posted on https://info.crazymeds.net

side effects, dosage, how to take & discontinue, uses, pros & cons, and more


US brand name: Luvox
Generic name: fluvoxamine

Other Forms: Luvox CR extended-release capsules

Class: Antidepressant, because Luvox is one of the first SSRIs.2 As far as approved uses goes, it’s an anxiolytic/anti-anxiety drug.

1.  Other brand names & branded generic names1

  • Anwu (Taiwan)
  • Dumirox (Korea, Spain, Uruguay)
  • Dumyrox (Greece, Portugal)
  • Faverin (Israel, Australia, Hong Kong, Ireland, Philippines, Singapore, Thailand, Turkey, UK)
  • Favoxil (Israel)
  • Fevarin (Bulgaria, Czech Republic, Denmark, Finland, Germany, Hungary, Italy, Netherlands, Norway, Poland, Russia, Sweden, Turkey)
  • Floxyfral (Austria, Belgium, France, Switzerland)
  • Fluvohexal (Germany)
  • Fluvoxin (India)
  • Lote (Taiwan)
  • Luvox (Argentina, Australia, Brazil, Canada, Costa Rica, El Salvador, Guatemala, Honduras, Indonesia, Japan, Malaysia, New Zealand, Nicaragua, Panama, Peru, South Africa, Taiwan, Venezuela)
  • Movox (Australia)
  • Voxamin (Colombia)

2.  FDA Approved Uses of Luvox (fluvoxamine) / Luvox CR

Obsessive-Compulsive Disorder

3.  Off-Label Uses of Luvox

4.  Luvox / Luvox CR pros and cons

4.1  Pros

  • Proven as the best med for OCD.
  • Generally less agitating than other SSRIs.
  • Tends to work faster than other SSRIs, except Lexapro.

4.2  Cons

  • The short half-life can make discontinuation difficult.
  • It doesn’t have as many drug-drug interactions as Provigil or fish oil, but it’s as bad, if not worse than warfarin when it comes to the ones it does have. E.g. Luvox + Cymbalta = effectively tripling your Cymbalta dosage.

5.  Luvox / Luvox CR Side Effects

5.1  Typical Luvox / Luvox CR Side Effects

The usual for SSRIs - headache, nausea, dry mouth, sweating, sleepiness or insomnia, and diarrhea or constipation, weight gain, loss of libido. Most everything will go away after a week or two, but the weight gain and loss of libido might stick around longer. Or permanently.

5.2  Not So Common fluvoxamine maleate Side Effects

Worsening of symptoms, be it anxiety, depression or OCD. Even if you’re taking Luvox for one thing you might get the symptoms of something else.3

5.3  Luvox / Luvox CR Freaky Rare Side Effects

Agoraphobia, fecal incontinence, priapism. Time to stay inside and make the freakiest scat video ever!

6.  Interesting Stuff Your Doctor Probably Won’t Tell You about Luvox / Luvox CR

  • Mixing caffeine and Luvox (fluvoxamine) can be intensely unpleasant. Your one cup of joe will suddenly become like five cups, and the effects will last six times as long.

The results indicate that intake of caffeine during fluvoxamine treatment may lead to caffeine intoxication.A fluvoxamine-caffeine interaction study.

  • However there is at least one dueling study that explains why people who drink coffee and take Luvox don’t completely flip out.

The increased plasma caffeine concentrations during coadministration with fluvoxamine were not accompanied by enhanced pharmacodynamic activity of caffeine. Several alerting actions of caffeine were observed using tests for mood, sedation, psychomotor performance and EEG, but none were augmented by coadministration of fluvoxamine. The lack of a significant caffeine–fluvoxamine pharmacodynamic interaction might be the result of a number of factors. The subjects who participated in this study, four out of seven of whom consumed caffeine-containing beverages on a regular basis, may have been tolerant to the stimulating effects of higher concentrations of caffeine, even though caffeine alone caused significant improvement in psychomotor performance and decreases in self-rated sedation compared with double-placebo administration. Caffeine doses in excess of 5 mg kg−1 are reportedly required to produce clinically important effects such as mild anxiety, respiratory stimulation, and cardiovascular actions. Caffeine doses in the present study (250 mg, approximately 3.5 mg kg−1) may not have been sufficient to produce adverse effects even after augmentation by fluvoxamine. However, the findings from this single-dose caffeine study predict extensive caffeine accumulation with daily caffeine ingestion and fluvoxamine treatment. Based upon our single dose caffeine data, simulated plasma caffeine concentrations once-daily caffeine ingestion (250 mg) and fluvoxamine treatment over 7 days are predicted to reach a range that might produce untoward CNS effects. Caffeine accumulation could be further augmented with the consumption of caffeine repeatedly throughout a 24-h period. Fluvoxamine impairs single-dose caffeine clearance without altering caffeine pharmacodynamics

  • In English: Most regular coffee drinkers can drink one cup of coffee a day while taking Luvox and they probably won’t have a problem.

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7.  Luvox / Luvox CR Dosage and How to Take Luvox (fluvoxamine)

7.1  Immediate release

The initial dose is 50 mg at bedtime, increased by 50 mg a day every four to seven days as needed until the maximum dose of 300 mg a day is reached. Like any SSRI I suggest starting out with 25mg and then increasing to 50mg after a week. If you don’t feel anything go up to 100mg, but stay there until you’ve given it a try for a month total (about two weeks at 100mg), otherwise it’ll just be a pain in the ass to stop it. Even at 100mg you’ll know after a month if Luvox is going to do something for you.

7.2  Controlled Extended release

Here Abbott & Jazz Pharma’s recommendation:

100 mg at bedtime, with weekly increases of 50 mg as tolerated to maximum therapeutic benefit, not to exceed 300 mg per day.--Luvox CR PI sheet

At least they kept Solvay’s lack of a target dosage. As much as I’d like to suggest starting at 50mg, as James pointed out, Luvox CR comes in only two dosages: 100mg & 150mg. So you’re pretty much stuck with starting at 100mg a day.

8.  How Long Luvox / Luvox CR Takes to Work

Like all SSRIs anywhere from a couple days to over a month. If you don’t feel any positive benefit after a two-three weeks, then you should talk to your doctor about either another SSRI and/or adding an antipsychotic to the mix.

9.  How to Stop Taking Luvox / Luvox CR (fluvoxamine maleate)

Your doctor should be recommending that you reduce your dosage 25–50mg every 4 days if you need to stop taking it.

While you have the option of reducing your dosage by 50mg a day with the CR form, since Jazz Pharma makes Luvox CR only in 100mg and 150mg capsules, that can be both complicated and expensive. A study specific to fluvoxamine withdrawal shows that if you stop taking Luvox abruptly you might wind up with SSRI discontinuation syndrome. Ya think?
So if your discontinuation seems harsh, and because fluvoxamine has such a short half-life and its pharmacokinetics are non-linear, talk to your doctor about getting a prescription for immediate-release fluvoxamine and go for a tapering of 12.5–25mg a day.

10.  Luvox / Luvox CR Half-Life & Average Time to Clear Out of Your System

With a half-life of 15.6 hours, the shortest of all true SSRIs4, Luvox (fluvoxamine) is out of your body in about 80 hours. Luvox CR has a half-life of about 16 hours, so there’s still not much difference.

11.  Days to Reach a Steady State

The steady state for Luvox is non-linear. That means if you change the dosage, the steady state gets hosed. So Solvay doesn’t publish any steady state data. Figure at least a week, maybe two, after your last dosage adjustment.

12.  Shelf life

3 years.


Note that Luvox (fluvoxamine) is not technically an antidepressant in the US, just everywhere else. Luvox is just one of two meds of which I’m aware that are officially approved only for OCD in the US. And why is it so good for OCD? It’s all about the sigma-1 receptor, and fluvoxamine likes sigma-1. Zoloft is another meds that is especially effective for anxiety disorders, and it is also sigma-1 agonists.

Solvay may have given up on Luvox, but in 2008 Abbott & Jazz Pharma brought brand-name Luvox back to the US market as Luvox CR extended-release capsules. How CR translates to extended release is beyond me. I can understand why they didn’t want to call it Luvox ER, because that looks and sounds too much like Effexor, and Elan Pharma’s fancy Spheroidal Oral Drug Absorption System (or SODAS) must “controlled” and not “extended,” or something like that.

Luvox CR originally had approval to treat social anxiety disorder (SAnD) as well as OCD. Unfortunately some data from the clinical trials were made public and the FDA pressured Jazz to “voluntarily withdraw the indication”.5

We know that nicotine makes you clear Luvox a lot faster and nicotine is an effective treatment for OCD. So what would happen if a poor metabolizer of CYP1A2 substrates with OCD combined Luvox with nicotine. Synergistic effect or just a wash?

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14.  Luvox Ratings, Reviews, & Other Sites of Interest

14.1  Rate Luvox

Give your overall impression of Luvox on a scale of 0 to 5.

Get all critical about Luvox

4 stars Rating 3.6 out of 5 from 132 criticisms.
Vote Distribution: 20 – 1 – 6 – 11 – 39 – 55

14.2  Rate this article

If you’re still feeling judgmental as well as just mental6, please boost or destroy my self-confidence by honestly (and anonymously) rating this article on a scale of 0 to 5. The more value-judgments the better, even if you can criticize my work only once.

Get all judgmental about the Luvox (fluvoxamine) Synopsis

4 stars Rates 3.7 out of 5 from 65 value judgments.
Vote Distribution: 11 – 0 – 2 – 2 – 21 – 29

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It’s always a good idea to check for drug-drug interactions yourself. Just because most people in the crazy meds business know about really important interactions (e.g. MAOIs and a lot of stuff, warfarin and everything on the planet) doesn’t mean the person who prescribed your meds told you about them, or the pharmacist has all the meds you take at their fingertips like they’re supposed to. Or they have the time to do their jobs properly when not dealing with complete idiots or playing Angry Farmers on the Faecesbooks.

These will stick around longer than AD side effects. More ways to be stuck-up at Straitjacket T-shirts. Individual stickers only $5. Packs of 10 and 50 available.
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You don’t have to buy anything. Look around the store. Tweet what you like to your Pinbook Circle. Do you have anything better to do right now?

14.4  Discussion board

If you have any questions not answered here, please see the Crazymeds Luvox discussion board.

Keep Crazymeds on the air.
Donate some spare electronic currency
you have floating around The Cloud

15.  References

  1. Luvox (fluvoxamine) Full US Prescribing Information
  2. Culm‐Merdek, Kerry E., Lisa L. Von Moltke, Jerold S. Harmatz, and David J. Greenblatt. “Fluvoxamine impairs single‐dose caffeine clearance without altering caffeine pharmacodynamics.” British journal of clinical pharmacology 60, no. 5 (2005): 486-493.
  3. Ishikawa, Masatomo, and Kenji Hashimoto. “The role of sigma-1 receptors in the pathophysiology of neuropsychiatric diseases.” Journal of Receptor, Ligand and Channel Research 3 (2010): 25-36.
  4. Stahl, Stephen M. Stahl’s Essential Psychopharmacology: Neuroscientific Basis and Practical Applications (Essential Psychopharmacology Series) Third edition Cambridge University Press 2008. ISBN:978–0521673761
  5. PDR: Physicians’ Desk Reference 2010 64th edition
  6. Diamond, Ronald J., MD Instant Psychopharmacology 2nd Edition W.W. Norton 2002. ISBN:978–0393703917
  7. Julien, Robert M. Ph.D, Claire D. Advokat, and Joseph Comaty Primer of Drug Action: A comprehensive guide to the actions, uses, and side effects of psychoactive drugs 12th edition Worth Publishers 2011. ISBN:978–1429233439
  8. Drummond, Edward, MD The Complete Guide to Psychiatric Drugs John Wiley & Sons 2000. ISBN:0471353701
  9. Healing Anxiety & Depression Daniel G. Amen, M.D., and Lisa C. Routh, M.D. © 2003. Published by G.P. Putnam’s Sons.
  10. Mosby’s Drug Consult 2007 (Generic Prescription Physician’s Reference Book Series)
1 The term "branded generic" has three meanings:
1) A generic drug produced by a generics manufacturer that is a wholly-owned subsidiary of the company that makes the branded version. E.g. Greenstone Pharmaceuticals makes gabapentin, and they are owned by Pfizer, who also own Parke-Davis, the makers of Neurontin.
2) A branded generic is also a generic drug given a 'brand' name by the manufacturer (e.g. Teva's Budeprion), but otherwise has the same active ingredient as the original branded version (Wellbutrin).
3) A branded generic is also a generic drug given a 'brand' name by the manufacturer (e.g. Sanofi-Aventis' Aplenzin, which is bupropion hydrobromide) and uses a salt of the active ingredient that is different from the original branded version and other generics (Wellbutrin, Budeprion and all the others are bupropion hydrochloride). We aren't sure if that really makes a difference or not. The FDA says they're the same thing. As usual, the data are contradictory, but most evidence indicates that the FDA is right and the differences are negligible.
For our purposes a "branded generic name" refers to the second and third definitions.

2 DU 23000 - the designation used prior to the assignment of the generic name fluvoxamine - was being tested for depression as far back as 1977. Fevarin was released in Switzerland in 1984, although it wasn't approved in the US until 1993.

3 Which seems to be a common trait with sigma-1 agonists.

4 Paxil CR has a half-life of 15-20 hours, while the immediate-release form has a half-life of 21 hours. No, I don't have those backwards. Yes, it makes no sense to me either, other than drug companies usually do a half-assed job in PK testing.

5 And they had to file the usual shitload of paperwork that accompanies any change to what a medication is prescribed for, or anything else that is in a PI sheet for that matter. Talk about adding insult to injury.

6 Thank you! I'll be here all weak. Be sure to tip your content provider. And don't try the veal, it's cruelicious!

If you have any questions not answered here, please see the Crazymeds Luvox discussion board. We welcome criticisms of the articles, notifications of bad links, site problems, consumer experiences with medications, etc. I’m not always able to write back. Hence I never answer questions about meds via e-mail that are answered by this or other articles. Especially if they have been repeatedly asked on the forum. That’s why we write these damn things. Questions about which meds are best for your condition should also be asked on the forum; because this is a free site, so the price of admission is making things easier for somebody else searching for the same answer. We don’t deal with children on the forum or in private because after doing this for ten years I don’t have the emotional stamina to deal with kids who have brain cooties. How to contact Crazymeds. — Jerod Poore, CME, Publisher Crazymeds (crazymeds.net)

Last modified on Friday, 29 August, 2014 at 19:55:53 by JerodPoorePage Author Date created
“Luvox (fluvoxamine): a Review for the Educated Consumer.” by Jerod Poore is copyright © Jerod Poore Published online 2011/03/17
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Luvox, and all other drug names on this page and used throughout the site, are a trademark of someone else. Luvox’s PI Sheet will probably have the name of the manufacturer and trademark owner (they’re not always the same company) at or near the very bottom. Or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing. It may of changed hands by the time you finished reading this article.

Page design and explanatory material by Jerod Poore, copyright © 2003 - 2015. All rights reserved.
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Almost all of the material on this site is by Jerod Poore and is copyright © 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, and 2015 Jerod Poore. Except, of course, the PI sheets - those are the property of the drug companies who developed the drugs the sheets are about - and any documents that are written by other people which may be posted to this site will remain the property of the original authors. You cannot reproduce this page or any other material on this site outside of the boundaries of fair use copying without the express permission of the copyright holder. That’s usually me, so just ask first. That means if want to print out a few pages to take to your doctor, therapist, counselor, support group, non-understanding family members or something like that - then that’s OK to just do. Go for it! Please. As long as you include this copyright notice and something along the lines of following disclaimer, I’m usually cool with it.

All rights reserved. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. If you still have questions about a medication or condition that were not answered on any of the pages you read, please ask them on Crazy Talk: the Crazymeds Forum.
The information on Crazymeds pertains to and is intended for adults. While some information about children and adolescents is occasionally presented (e.g. US FDA approvals), pediatric-specific data such as dosages, side effects, off-label applications, etc. are rarely included in the articles on drugs or discussed on the forum. If you are looking for information regarding meds for children you’ll have to go somewhere else. Plus we are big pottymouths and talk about S-E-X a lot.
Know your sources!
Nobody on this site is a doctor, a therapist, or a pharmacist. We don’t portray them either here or on TV. Only doctors can diagnose and treat an illness. While it’s not as bad as it used to be, some doctors still get pissed off by patients who know too much about medications, so tread lightly when and where appropriate. Diagnosing yourself from a website is like defending yourself in court, you suddenly have a fool for a doctor. Don’t be a cyberchondriac, thinking you have every disease you see a website about, or that you’ll get every side effect from every medication1. Self-prescribing is as dangerous as buying meds from fraudulent online pharmacies that promise you medications without prescriptions.
All information on this site has been obtained from the medications’ product information / summary of product characteristic (PI/SPC) sheets and/or medication guides - which is all you get from sites like WebMD, RxList, NAMBLA NAMI, etc., the sources that are referenced throughout the site, our personal experience and the experiences family, friends, and what people have reported on various reputable sites all over teh intergoogles. As such the information presented here is not intended as a substitute for real medical advice from your real doctor, just a compliment to it. You should never, ever, replace what a real doctor tells you with something from a website on the Internet. The farthest you should ever take it is getting a second opinion from another real doctor. Educate yourself - always read the PI/SPC sheet or medication guide/patient information leaflet (PIL) that comes with your medications and never ever throw them away. OK, you can throw away duplicate copies, but keep at least one, as that’s your proof of purchase of having taken a med in case a doctor doubts your medical history. Plus they take up less space than a bottle, although keeping one inside of a pill bottle is even better.
Crazymeds is not responsible for the content of sites we provide links to. We like them, or they’re paid advertisements, or they’re something else we think you should read to help you make an informed decision about a particular med. Sometimes they’re more than one of those things. But what’s on those sites is their business, not ours.
Very little information about visitors to this site is collected or saved. From time to time I look at search terms used and which pages they bring up in an effort to make the information I present more relevant. And the country of origin, just because I’m geeky like that. That’s about it. Depending on how you feel about Schrodinger, our privacy policy should either assuage or exacerbate your paranoia.
Crazymeds is optimized for ridiculously large screens and browsers that don’t block ads. I use Firefox and Chrome, running under Windows 72. On a computer that sits on top of my desk. With a 23 inch monitor. Hey, at least you can make the text larger or smaller by clicking on the + or - buttons in the upper right hand corner. If you have Java enabled. Like 99% of the websites on the planet, Crazymeds is hosted on domain running an open source operating system with a variety of open source applications, including the software used to display what you’ve been reading. As such Crazymeds is not responsible for whatever weird shit your browser does or does not do when you read this site3.
No neurologists, psychiatrists, therapists or pharmacists were harmed in the production of this website. Use only as directed. Void where prohibited. Contains nuts. Certain restrictions may apply. All data are subject to availability. Not available on all mobile devices, in the 12 Galaxies Guiltied to a Zegnatronic Rocket Society, or in all dimensions of reality. Hail Xenu!

‘Everything is true, nothing is permitted.’ - Jerod Poore

1 While there are plenty of books to help you with hypochondria, for some reason there’s not much in the way of websites. Then again, staying off of the Internet is a large part of curing/managing the disorder.

2 Remember kids, Microsloth operating systems are like TOS Star Trek movies with in that every other one sucks way, way more. With TOS Star Trek movies you don’t want to bother watching the odd-numbered ones. With Microsloth OS you don’t want to buy and install the even-numbered ones. Anyone who remembers ME and Vista knows what I mean.

3 Have I mentioned how open source operating systems for commercial applications is one of the dumbest ideas in the history of dumb ideas?* I don’t even need my big-ass rant any more. Heartbleed has made my case for me. And that’s just the one that got all the media attention. The very nature of an open source operating system makes security as much of an illusion as anonymity on teh Intergoogles. Before you flip out too much: the domain Crazymeds is hosted on uses a version of SSL that is not affected by the Heartbleed bug. That’s one of the many reasons why I pay a lot of money and keep this site on Lunarpages.

* Yes, I know I’m using open source browsers. I also test the site using the now-defunct IE and Safari browsers. Their popularity - and superiority - killed IE and Safari, so that’s why I rely on the open source browsers. It’s like brand vs. generic meds. Sometimes the generic is better than the brand.

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