17 U.S. Code § 107 - Limitations on exclusive rights: Fair use
Notwithstanding the provisions of sections 106 and 106A, the fair use of a copyrighted work, including such use by reproduction in copies or phonorecords or by any other means specified by that section, for purposes such as criticism, comment, news reporting, teaching (including multiple copies for classroom use), scholarship, or research, is not an infringement of copyright. In determining whether the use made of a work in any particular case is a fair use the factors to be considered shall include—
(1) the purpose and character of the use, including whether such use is of a commercial nature or is for nonprofit educational purposes [all mirrored content falls under this clause, any ads present are mirrored from the original site, mirrored content earns me no revenue whatsoever];
(2) the nature of the copyrighted work [this is a unique resource for the mentally ill, and preservation of it can be argued to be incredibly important];
(3) the amount and substantiality of the portion used in relation to the copyrighted work as a whole; and
(4) the effect of the use upon the potential market for or value of the copyrighted work. [absolutely none whatsoever, as the original work no longer exists anywhere else (outside of whatever bits and pieces archive.org managed to capture) - the original site was intermittantly completely unavailable for a extended period of time before its SSL certificate expired (and was never renewed), and eventually the site went offline for good, then finally the DNS records were removed at some point prior to May 2018, so at this point it is well beyond the 'dead and rotting' stage]
The fact that a work is unpublished shall not itself bar a finding of fair use if such finding is made upon consideration of all the above factors.

This domain is not controlled by Jerod Poore, and I will NOT continue redirecting traffic from this domain to crazymeds.us [as I formerly did] while Jerod continues with his immature temper tantrum over adblock or continues to fail to maintain his site, fucking over his entire community and countless visitors in the process. [belated clarification: with specific regards to the adblock drama I was referring to Poore at one point replacing his entire site with a single page complaining about the amount of revenue lost to users with ad blocking active, which is something that I took extreme exception to because this affected ALL visitors to the site regardless of if or if not they were actually using ad blocking]
This mirror is unfortunately incomplete (and very slightly outdated), as /CrazyTalk/ was not included when I scraped the site (it was far too large to scrape given the site's extremely poor performance, my wish to avoid worsening the poor performance further, and other factors). If you're looking for a replacement forum, I suggest visiting https://www.crazyboards.org/forums/. There are issues with many of the mirrored pages, I am working on identifying and fixing them, but I do not have the time to address every single issue at this moment (although by now the majority of these issues have been resolved). Dynamic content is obviously completely broken (this is beyond my control), and the loss of /CrazyTalk/ is quite bad given how much good user-generated info was on there, but you have Jerod to "thank" for that. Maybe I'll bring it back online at some point, but it wouldn't be the same as before. For now, I suggest visiting CrazyBoards instead.
Note (Oct 9 2018): Infrequent additional updates regarding the status of this site will be posted on https://info.crazymeds.net


side effects, dosage, how to take & discontinue, uses, pros & cons, and more

>


MultiPageMedicationArticle Article Index | Approved & Off-label Uses

Brand & Generic Names; Drug Class

US brand name: MultiPageMedicationArticle
Generic name: longmed
Drug Class: Miscellaneous
Learn More about MultiPageMedicationArticle’s Generic & Worldwide Availability

MultiPageMedicationArticle’s Approved & Off-Label Uses (Indications)

US FDA Approved Treatment(s)

Explaining the pages of a multi-page medication article

Popular Off-Label Uses

If you read the page on one-page med articles, you’ll probably notice a lot of copy & paste repetition. Not all of it on this page, though.

  • FDA-approved uses/indications will be listed here.
  • If a drug has multiple forms the different forms will often have different approvals.
  • There usually won’t be anywhere near as much detail in any of these fields as on the one-page articles. That’s what the other pages are for!
  • Wanna know more about MultiPageMedicationArticle’s drug classes and names? Click on the link to the MultiPageMedicationArticle’s Generic & Worldwide Availability above.
  • How about its approved and off-label uses? Click on the link to MultiPageMedicationArticle’s Approved & Off-label Uses below.
  • Sorry about all the bullshit “Learn more about” and whatnot. I was desperately trying to get these pages back into the top ten search results. I’ll think of something better.

Learn More about MultiPageMedicationArticle’s Approved & Off-label Uses

How Long Until MultiPageMedicationArticle Starts Working (Onset of Action)

Isn’t this one of the most important question your doctor or pharmacist should be able to answer? Yes, it is. Did you remember to ask them that?

The short answer will be here. The standard “3–4 weeks for most SSRIs, up to 6 weeks for Prozac, while Lexapro can start working in two weeks or less.” Longer answers will be on the Efficacy and Comparisons with Other Meds Page.

Likelihood of Working

Same as with how long it takes to work. With more detail, off-label uses, and comparisons with other meds.

Learn how MultiPageMedicationArticle Compares with Other Drugs

How to Take MultiPageMedicationArticle

Taking a med is something your doctor and/or pharmacist should explain to you. In case you didn’t quite understand it, or want to get an idea of what it’s like, we’ll summarize both the manufacturer’s guidelines from the prescribing information (PI) and, since we often disagree, our suggestion to talk to your doctor about.

The Taking and Discontinuing Page will have excerpts from the PI and details of our suggestions.

How to Stop Taking MultiPageMedicationArticle (Discontinue, Withdrawal)

How you stop taking a drug can be just as, if not more important than how you take it.

As with titration, if the PI has it, we’ll summarize it here and quote the whole thing on the Taking and Discontinuing Page. The same goes for our suggestions.

Learn More about Taking and Discontinuing MultiPageMedicationArticle



MultiPageMedicationArticle’s Pros and Cons

Pros

  • A short list of why this might be the drug for you.
  • Why it’s better for its approved & off-label uses than other medications that treat the same things.
  • And/or why it sucks less than those meds.

Cons

  • A short list of why this might not be the drug for you.
  • Why it’s not as good for its approved & off-label uses than other medications that treat the same things.
  • And/or why it sucks more than those meds.

Interesting Stuff your Doctor Probably didn’t Tell You about MultiPageMedicationArticle

  • “Interesting” is really subjective.
    • Sometimes it can mean “important.”
    • Either way, it’s only the highlights here.
  • More pros, cons, and interesting stuff if any, will be on the In-Depth Pros & Cons page.
  • As will more details about them.

Best Known for

There’s usually one, sometimes two, things a drug is known for. Lamictal has The Rash. Effexor has the discontinuation syndrome from hell. Topamax will make you skinny and stupid.

Originally this was going to be an entire page itself. That didn’t work.
In-Depth Pros & Cons

MultiPageMedicationArticle’s Potential Side Effects (Adverse Reactions)

Typical Side Effects

  • Side effects are divided into three categories: Typical, Uncommon, and Freaky Rare.
  • Typical/common side effects (“adverse reactions” in doctorese) are those that practically everyone who takes a medication is going to get.
  • On a medication page this part invariably starts with “The usual for [the class of the med]…”.
    • For SSRIs, SNRIs, and TCAs that can be most, if not all of the typical side effects.
    • The main difference for each med in those classes is how long the typical side effects will last.
  • Most common side effects either go away or subside to something you can live with in two to four weeks.
  • A lot of the good stuff, like how to deal with side effects, will be on the Side Effects page.

Uncommon Side Effects

  • These are the side effects that happen, but not all that often.
  • File under “don’t be surprised if you get one or more of these.”
  • How long they can last is highly variable, from a few days to as long as you’re taking the drug.
    • The most frustrating is “You’ll know it’s a temporary side effect when it stops.”
    • Unfortunately there are a very few side effects where that timeline applies even after you stop taking the med.

Freaky Rare Side Effects

  • My favorite type of side effect, only because one person’s misfortune1 is another person’s comedy. Sometimes.
  • The key words here are:
    • “Rare”, which, depending on the popularity of the med and nature of the available side effects, is in the neighborhood of fewer than one person in 10,000 to fewer than one person in 100,000.
    • And “freaky,” which isn’t as subjective as it seems
  • The Side Effects page will have things like excerpts from case reports

Learn More about MultiPageMedicationArticle’s Side Effects.
TMI at times

What You Really Need to be Careful About

If a drug has a “Black Box Warning” - something potentially bad enough that it is the first thing in the PI, written in a bold and larger typeface, all caps, and printed/displayed within a black box - that will be summarized here.

If there is one, the entire black box warning will be on the Warnings and Noted Traits Page

MultiPageMedicationArticle’s Black Box and Other Warnings, Pregnancy Category, etc.


Stick to your treatment plan with buttons and magnets. 2.25″ $4 & 3.5″ $4.50 at Straitjacket T-shirts
Pile of Pills buttons at Straitjacket T-shirts
Pile of Pills
Vaccines Cause Immunity buttons at Straitjacket T-shirts
Vaccines Cause Immunity
Medicated For Your Protection magnets at Straitjacket T-shirts
Medicated For Your Protection
Fuck Bipolar buttons at Straitjacket T-shirts
Fuck Bipolar


Pharmacology

longmed’s Half-Life & How Long Until It Clears Your System

Plasma half-life: About all the pharmacokinetics 99% of Crazymeds readers want. It can be total information overload on the PK page.
longmed’s Pharmacokinetics Information Overload

Half-life is the average time it takes for you to process half of the drug’s active ingredient. If a drug has a half-life of around 24 hours and you take a dose of 100mg, you’ll have roughly the equivalent a 50mg dose after one day, a 25mg dose after two days, and so on. The rule of thumb is: multiply the half-life by five and you get how long it is for the dose you took to be cleared from your bloodstream, so there’s nothing swimming around to attach itself to your brain and start doing stuff2. That’s called “plasma clearance.” Complete clearance is a complex equation based on a lot of factors which may or may not: be published in the PI sheet, include personal data like your weight, or even completely figured out by corporate and independent researchers. It usually winds up being 2–5 days after plasma clearance no matter what3, but can take weeks. Sometimes a drug will clear from your brain and other organs before it clears from your blood. If we’ve found the complete clearance, or how to calculate it if it requires things like your weight and what your piss looks like, you’ll find that on longmed’s pharmacokinetics page.

How longmed Works

the current best guess at any rate
The keyword here is “brief”. We try to make it as brief and understandable as possible, and put the pharmacology student-level details on the Pharmacodynamics Page.

Learn More than You Probably Ever Wanted to Know about How longmed Works
AKA mechanism/method of action, pharmacodynamics

Ratings, Reviews, Comments, PI Sheet, and More

MultiPageMedicationArticle Comments

  • This will often be the personal experiences of the author.
  • Even though there’s an entire page for extended comments, it’s rarely used.
    • In fact, with all the other pages for extended attributes, the comments section for a lot of meds are blank!
  • A couple more things to cover about these articles:
    • Ratings. Anyone can rate the med and the article.
    • The way the wiki software is written you can’t rate both at the same time. It’s pick one, click submit, scroll back down, pick the other, click submit.
      • Don’t blame me, I didn’t write it.
    • Please rate this guide. I have no idea how much good any of this crap does.
  • I know there is way too much in the way of ads for Amazon and CafePress crap. Sorry.
  • I’m sure I’ll come up with more.

Extended Comments
As if I didn’t go on long enough already.

Rate MultiPageMedicationArticle

Give your overall impression of MultiPageMedicationArticle on a scale of 0 to 5.

Get all critical about MultiPageMedicationArticle

0 stars Everybody hates me.


Rate this article

If you’re still feeling judgmental as well as just mental4, please boost or destroy my self-confidence by honestly (and anonymously) rating this article on a scale of 0 to 5. The more value-judgments the better, even if you can criticize my work only once.

Get all judgmental about the MultiPageMedicationArticle (longmed) Overview

0 stars Everybody hates me.


Pages and Forum Topics Google Thinks are Relevant to Your Mental Health

MultiPageMedicationArticle Consumer Reviews, Comments & Experiences

Discussion board

Consumer experiences with and questions about MultiPageMedicationArticle on Crazymeds MultiPageMedicationArticle discussion board. Sign up for a free account to post your own.

More Allegedly Useful Links. Mostly official sites, PI sheet-equivalents5 from countries other than the US, and consumer/patient review sites.

Drugs.com’s drug-drug and drug-food interaction checker

It’s always a good idea to check for drug-drug interactions yourself. Just because most people in the crazy meds business know about really important interactions (e.g. MAOIs and a lot of stuff, warfarin and everything on the planet) doesn’t mean the person who prescribed your meds told you about them, or the pharmacist has all the meds you take at their fingertips like they’re supposed to. Or they have the time to do their jobs properly when not dealing with complete idiots or playing Angry Farmers on the Faecesbooks.



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References

  1. MultiPageMedicationArticle’s Full US Prescribing Information
  2. Faught, Edward. “Topiramate in the treatment of partial and generalized epilepsy.” Neuropsychiatric disease and treatment 3.6 (2007): 811-821.

This is new for the multi-page format. Currently the bibliography is on its own page. I’m changing that for various reasons. Until it’s filled you’re going to see "$BigBibli0" all over the place. Here’s Lamictal’s:

Stahl’s Essential Psychopharmacology: Neuroscientific Basis and Practical Applications (Essential Psychopharmacology Series) 3rd edition Stephen M. Stahl

Antiepileptic Drugs René H. Levy, Richard H. Mattson, Brian S. Meldrum, Emilio Perucca, et al.

U.S. Lamictal PI Sheet GlaxoSmithKline last revised December 2011

Clinical Handbook of Psychotropic Drugs 18th edition Adil S. Virani, K. Bezchlibnyk-Butler, J. Jeffries

A Primer of Drug Action: A Comprehensive Guide to the Actions, Uses, and Side Effects of Psychoactive Drugs Robert M. Julien, Claire D. Advokat, Joseph E. Comaty

The Prescriber’s Guide (Essential Psychopharmacology Series) 3rd edition Stephen M. Stahl

Epilepsy: Patient and Family Guide Orrin Devinsky

PDR: Physicians’ Desk Reference 2010 64th edition

Mosby’s Drug Consult 2007 (Generic Prescription Physician’s Reference Book Series)

Clinical Neurology for Psychiatrists 5th edition David Myland Kaufman

Bipolar disorder and mechanisms of action of mood stabilizers Stanley I. Rapoport, Mireille Basselin, Hyung-Wook Kim, and Jagadeesh S. Rao Brain Research Reviews Volume 61, Issue 2, October 2009

Ion channels and epilepsy T.D. Graves QJM: An International Journal of Medicine Volume 99, Issue 4, April 2006

Steady‐state Pharmacokinetics of Lamotrigine when Converting from a Twice‐daily Immediate‐release to a Once‐daily Extended‐release Formulation in Subjects with EpilepsyDebra J. Tompson et al. Epilepsia Volume 49, Issue 3 Pages:410–417, 2008

Adjunctive therapy for the treatment of primary generalized tonic-clonic seizures: focus on once-daily lamotrigine

Medical Management of Bipolar Disorder: A Pharmacologic Perspective Matthew A. Fuller, PharmD, BCPS, BCPP, FASHP Annals of Clinical Psychiatry Vol. 22, No. 04 / November 2010

Pharmacotherapeutics of epilepsy: use of lamotrigine and expectations for lamotrigine extended release Mary Ann Werz Therapeutics and Clinical Risk Management 2008 October; Vol 4 Issue 5 pages: 1035–1046

Lamotrigine and therapeutic drug monitoring: retrospective survey following the introduction of a routine service Raymond G Morris et al. British Journal of Clinical Pharmacology 1998 December Volume 46 Issue 6 pages: 547–551.

Review of the available evidence on Lamotrigine for Epilepsy for the WHO Model List of Essential Medicines

Lamotrigine pharmacokinetic evaluation in epileptic patients submitted to VEEG monitoring European Journal of Clinical Pharmacology A. M. Almeida et al. 2006 Volume 62 pages: 737–742

Tobacco habits modulate autosomal dominant nocturnal frontal lobe epilepsy

Truly “Rational” Polytherapy: Maximizing Efficacy and Minimizing Drug Interactions, Drug Load, and Adverse Effects

Drug interactions involving the new second-and third-generation antiepileptic drugs

Basic mechanisms of antiepileptic drugs and their pharmacokinetic/pharmacodynamic interactions: an update

“Targets for antiepileptic drugs in the synapse” Cecilie Johannessen Landmark Medical Science Monitor Volume 13, Issue 1, January 2007

MultiPageMedicationArticle Article Index | Approved & Off-label Uses


1 Warning: Footnote '#rare' referenced but not defined.

2 Based on Julien's calculations from A Primer of Drug Action, the half-life multiplied by five is the generally accepted estimate of how long it takes a single dose of any given drug to be eliminated from the blood stream/plasma of someone with a normal metabolism. That's also the rough estimate for steady stage if they can't get, or won't provide a number for that.

3 For crazy meds. I have no idea what the average complete clearance is for other types of medications. For all I know there are drugs that utterly vanish from your system in under five passes, and others that won't let go of your squishy bits for years after you stop taking them.

4 Thank you! I'll be here all weak. Be sure to tip your content provider. And don't try the veal, it's cruelicious!

5 These include: Canada's Product Monographs (PM), New Zealand's Medicine Data Sheets (MDS), the EU's European Public Assessment Reports (EPAR), and the Summary of Product Characteristics (SPC) used in Britain, Ireland, and many other places.


If you have any questions not answered here, please see the Crazymeds MultiPageMedicationArticle discussion board. We welcome criticisms of the articles, notifications of bad links, site problems, consumer experiences with medications, etc. I’m not always able to write back. Hence I never answer questions about meds via e-mail that are answered by this or other articles. Especially if they have been repeatedly asked on the forum. That’s why we write these damn things. Questions about which meds are best for your condition should also be asked on the forum; because this is a free site, so the price of admission is making things easier for somebody else searching for the same answer. We don’t deal with children on the forum or in private because after doing this for ten years I don’t have the emotional stamina to deal with kids who have brain cooties. How to contact Crazymeds. — Jerod Poore, CME, Publisher Crazymeds (crazymeds.net)


Last modified on Thursday, 29 May, 2014 at 14:34:34 by JerodPoorePage Author Date created
“MultiPageMedicationArticle (longmed): a Review for the Educated Consumer.” by Jerod Poore is copyright © 2014 Jerod Poore Published online 1969/12/31
Citation options to copy & paste into your article:
Plain text:Poore, Jerod. “MultiPageMedicationArticle (longmed): a Review for the Educated Consumer.” Crazymeds (crazymeds.net). (2014).
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MultiPageMedicationArticle, and all other drug names on this page and used throughout the site, are a trademark of someone else. MultiPageMedicationArticle’s PI Sheet will probably have the name of the manufacturer and trademark owner (they’re not always the same company) at or near the very bottom. Or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing. It may of changed hands by the time you finished reading this article.




Page design and explanatory material by Jerod Poore, copyright © 2003 - 2015. All rights reserved.
Keep up with Crazymeds and and/or my slow descent into irreparable madness boring life. Pick your preferred social media target(s):

Almost all of the material on this site is by Jerod Poore and is copyright © 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, and 2015 Jerod Poore. Except, of course, the PI sheets - those are the property of the drug companies who developed the drugs the sheets are about - and any documents that are written by other people which may be posted to this site will remain the property of the original authors. You cannot reproduce this page or any other material on this site outside of the boundaries of fair use copying without the express permission of the copyright holder. That’s usually me, so just ask first. That means if want to print out a few pages to take to your doctor, therapist, counselor, support group, non-understanding family members or something like that - then that’s OK to just do. Go for it! Please. As long as you include this copyright notice and something along the lines of following disclaimer, I’m usually cool with it.



All rights reserved. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. If you still have questions about a medication or condition that were not answered on any of the pages you read, please ask them on Crazy Talk: the Crazymeds Forum.
The information on Crazymeds pertains to and is intended for adults. While some information about children and adolescents is occasionally presented (e.g. US FDA approvals), pediatric-specific data such as dosages, side effects, off-label applications, etc. are rarely included in the articles on drugs or discussed on the forum. If you are looking for information regarding meds for children you’ll have to go somewhere else. Plus we are big pottymouths and talk about S-E-X a lot.
Know your sources!
Nobody on this site is a doctor, a therapist, or a pharmacist. We don’t portray them either here or on TV. Only doctors can diagnose and treat an illness. While it’s not as bad as it used to be, some doctors still get pissed off by patients who know too much about medications, so tread lightly when and where appropriate. Diagnosing yourself from a website is like defending yourself in court, you suddenly have a fool for a doctor. Don’t be a cyberchondriac, thinking you have every disease you see a website about, or that you’ll get every side effect from every medication1. Self-prescribing is as dangerous as buying meds from fraudulent online pharmacies that promise you medications without prescriptions.
All information on this site has been obtained from the medications’ product information / summary of product characteristic (PI/SPC) sheets and/or medication guides - which is all you get from sites like WebMD, RxList, NAMBLA NAMI, etc., the sources that are referenced throughout the site, our personal experience and the experiences family, friends, and what people have reported on various reputable sites all over teh intergoogles. As such the information presented here is not intended as a substitute for real medical advice from your real doctor, just a compliment to it. You should never, ever, replace what a real doctor tells you with something from a website on the Internet. The farthest you should ever take it is getting a second opinion from another real doctor. Educate yourself - always read the PI/SPC sheet or medication guide/patient information leaflet (PIL) that comes with your medications and never ever throw them away. OK, you can throw away duplicate copies, but keep at least one, as that’s your proof of purchase of having taken a med in case a doctor doubts your medical history. Plus they take up less space than a bottle, although keeping one inside of a pill bottle is even better.
Crazymeds is not responsible for the content of sites we provide links to. We like them, or they’re paid advertisements, or they’re something else we think you should read to help you make an informed decision about a particular med. Sometimes they’re more than one of those things. But what’s on those sites is their business, not ours.
Very little information about visitors to this site is collected or saved. From time to time I look at search terms used and which pages they bring up in an effort to make the information I present more relevant. And the country of origin, just because I’m geeky like that. That’s about it. Depending on how you feel about Schrodinger, our privacy policy should either assuage or exacerbate your paranoia.
Crazymeds is optimized for ridiculously large screens and browsers that don’t block ads. I use Firefox and Chrome, running under Windows 72. On a computer that sits on top of my desk. With a 23 inch monitor. Hey, at least you can make the text larger or smaller by clicking on the + or - buttons in the upper right hand corner. If you have Java enabled. Like 99% of the websites on the planet, Crazymeds is hosted on domain running an open source operating system with a variety of open source applications, including the software used to display what you’ve been reading. As such Crazymeds is not responsible for whatever weird shit your browser does or does not do when you read this site3.
No neurologists, psychiatrists, therapists or pharmacists were harmed in the production of this website. Use only as directed. Void where prohibited. Contains nuts. Certain restrictions may apply. All data are subject to availability. Not available on all mobile devices, in the 12 Galaxies Guiltied to a Zegnatronic Rocket Society, or in all dimensions of reality. Hail Xenu!

‘Everything is true, nothing is permitted.’ - Jerod Poore


1 While there are plenty of books to help you with hypochondria, for some reason there’s not much in the way of websites. Then again, staying off of the Internet is a large part of curing/managing the disorder.

2 Remember kids, Microsloth operating systems are like TOS Star Trek movies with in that every other one sucks way, way more. With TOS Star Trek movies you don’t want to bother watching the odd-numbered ones. With Microsloth OS you don’t want to buy and install the even-numbered ones. Anyone who remembers ME and Vista knows what I mean.

3 Have I mentioned how open source operating systems for commercial applications is one of the dumbest ideas in the history of dumb ideas?* I don’t even need my big-ass rant any more. Heartbleed has made my case for me. And that’s just the one that got all the media attention. The very nature of an open source operating system makes security as much of an illusion as anonymity on teh Intergoogles. Before you flip out too much: the domain Crazymeds is hosted on uses a version of SSL that is not affected by the Heartbleed bug. That’s one of the many reasons why I pay a lot of money and keep this site on Lunarpages.

* Yes, I know I’m using open source browsers. I also test the site using the now-defunct IE and Safari browsers. Their popularity - and superiority - killed IE and Safari, so that’s why I rely on the open source browsers. It’s like brand vs. generic meds. Sometimes the generic is better than the brand.

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