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Notwithstanding the provisions of sections 106 and 106A, the fair use of a copyrighted work, including such use by reproduction in copies or phonorecords or by any other means specified by that section, for purposes such as criticism, comment, news reporting, teaching (including multiple copies for classroom use), scholarship, or research, is not an infringement of copyright. In determining whether the use made of a work in any particular case is a fair use the factors to be considered shall include—
(1) the purpose and character of the use, including whether such use is of a commercial nature or is for nonprofit educational purposes [all mirrored content falls under this clause, any ads present are mirrored from the original site, mirrored content earns me no revenue whatsoever];
(2) the nature of the copyrighted work [this is a unique resource for the mentally ill, and preservation of it can be argued to be incredibly important];
(3) the amount and substantiality of the portion used in relation to the copyrighted work as a whole; and
(4) the effect of the use upon the potential market for or value of the copyrighted work. [absolutely none whatsoever, as the original work no longer exists anywhere else (outside of whatever bits and pieces archive.org managed to capture) - the original site was intermittantly completely unavailable for a extended period of time before its SSL certificate expired (and was never renewed), and eventually the site went offline for good, then finally the DNS records were removed at some point prior to May 2018, so at this point it is well beyond the 'dead and rotting' stage]
The fact that a work is unpublished shall not itself bar a finding of fair use if such finding is made upon consideration of all the above factors.

This domain is not controlled by Jerod Poore, and I will NOT continue redirecting traffic from this domain to crazymeds.us [as I formerly did] while Jerod continues with his immature temper tantrum over adblock or continues to fail to maintain his site, fucking over his entire community and countless visitors in the process. [belated clarification: with specific regards to the adblock drama I was referring to Poore at one point replacing his entire site with a single page complaining about the amount of revenue lost to users with ad blocking active, which is something that I took extreme exception to because this affected ALL visitors to the site regardless of if or if not they were actually using ad blocking]
This mirror is unfortunately incomplete (and very slightly outdated), as /CrazyTalk/ was not included when I scraped the site (it was far too large to scrape given the site's extremely poor performance, my wish to avoid worsening the poor performance further, and other factors). If you're looking for a replacement forum, I suggest visiting https://www.crazyboards.org/forums/. There are issues with many of the mirrored pages, I am working on identifying and fixing them, but I do not have the time to address every single issue at this moment (although by now the majority of these issues have been resolved). Dynamic content is obviously completely broken (this is beyond my control), and the loss of /CrazyTalk/ is quite bad given how much good user-generated info was on there, but you have Jerod to "thank" for that. Maybe I'll bring it back online at some point, but it wouldn't be the same as before. For now, I suggest visiting CrazyBoards instead.
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side effects, dosage, how to take & discontinue, uses, pros & cons, and more


Table of Contents (hide)

  1. 1. Other brand names & branded generic names1
  2. 2. FDA Approved Uses of Stavzor (valproic acid delayed release)
  3. 3. FDA Approved Uses of Depakene (valproic acid)
  4. 4. Off-Label Uses of Stavzor (valproic acid delayed release) and Depakene (valproic acid)
  5. 5. Stavzor & Depakene (valproic acid) Pros and Cons
    1. 5.1 Pros
    2. 5.2 Cons
  6. 6. Stavzor (valproic acid) Side Effects
    1. 6.1 Stavzor (valproic acid) Typical Side Effects
    2. 6.2 Not So Common Side Effects
    3. 6.3 Freaky Rare Side Effects
  7. 7. Interesting Stuff Your Doctor Probably Won’t Tell You about Stavzor (valproic acid) Delayed Release Capsules
    1. 7.1 Interesting Stuff about Valproic Acid and Valproates in General
  8. 8. Stavzor (valproic acid) Delayed Release Capsules Dosage and How to Take Stavzor (valproic acid) Delayed Release Capsules
    1. 8.1 Bipolar Mania
    2. 8.2 Migraine
    3. 8.3 Epilepsy
  9. 9. How Long Stavzor (valproic acid delayed release) & Depakene (valproic acid) Take to Work
    1. 9.1 Bipolar Disorder
    2. 9.2 Epilepsy
    3. 9.3 Migraines
  10. 10. How to Stop Taking Stavzor (valproic acid delayed release) and Depakene (valproic acid)
  11. 11. Stavzor (valproic acid delayed release) and Depakene (valproic acid) Half-Life & Average Time to Clear Out of Your System
  12. 12. Days to Reach a Steady State
  13. 13. Shelf life
  14. 14. How Stavzor (valproic acid delayed release) and Depakene (valproic acid) Work
  15. 15. Comments
  16. 16. Stavzor Ratings, Reviews, & Other Sites of Interest
    1. 16.1 Rate Stavzor
    2. 16.2 Rate this article
    3. 16.3 Full US PI sheet, Global SPCs & PILs, Other Consumer Review & Rating Sites, check for drug-drug interactions
    4. 16.4 Discussion board
  17. 17. References
US brand name: Stavzor
Generic name: valproic acid

Other Forms: The immediate-release form under the brand name Depakene (and numerous generics) is available in capsules and as syrup

Class: Antiepileptic drug (AED)/ Anticonvulsant (AC) - specifically a valproate

1.  Other brand names & branded generic names1

  • Depakene - US brand name for immediate-release valproic acid
  • There are so many brand and branded generic names in so many different countries for regular valproic acid, but there’s no point in listing them here. Aside from being lazy, if you’re prescribed a particular brand of valproic acid, valproic acid itself, or any valproate other than Stavzor it’s going to be totally random-seeming as to what you get.

2.  FDA Approved Uses of Stavzor (valproic acid delayed release)

  • Acute treatment of manic episodes associated with bipolar disorder
  • Monotherapy (by itself) and adjunctive therapy (with another med) of complex partial seizures and simple and complex absence seizures
  • Adjunctive therapy in patients with multiple seizure types that include absence seizures
  • Prophylaxis (prevention) of migraine headaches

3.  FDA Approved Uses of Depakene (valproic acid)

  • Monotherapy and adjunctive therapy in the treatment of patients with complex partial seizures that occur either in isolation or in association with other types of seizures
  • Monotherapy and adjunctive therapy in the treatment of simple and complex absence seizures
  • Adjunctive therapy in patients with multiple seizure types which include absence seizures.

4.  Off-Label Uses of Stavzor (valproic acid delayed release) and Depakene (valproic acid)

In spite of it being on the market for four years, I can’t find anything in the way of off-label uses specific to Stavzor. Old-fashioned Depakene has a shitload. Here is just a small sample:

5.  Stavzor & Depakene (valproic acid) Pros and Cons

5.1  Pros

Proven to be effective for wide spectrum of epileptic disorders, as well as migraines and bipolar mania. Valproic acid has been around for so long (approved for use in France since 1967) that the long-term effects are well known and well documented. If you can get past the initial side effects and get used to a valproate medication, you probably don’t have to worry about anything biting your ass in the long run. In that your doctor should know all the potentially serious bad shit that can happen, like liver failure, and how to prevent it, like making you get a liver function test between one and four times a year2.

5.2  Cons

When you first take a valproate, or take one at high dosages, the side effects suck donkey dong! Especially since they tend to start you off at a high dosage for bipolar disorder. The valproates are among the harshest of commonly-prescribed meds to take. Everyone (read: the bipolar) hates them so much that they’ve given the entire class of anticonvulsants a bad name.

6.  Stavzor (valproic acid) Side Effects

6.1  Stavzor (valproic acid) Typical Side Effects

The usual for antiepileptic drugs - strange dreams, wanting to sleep a lot, your memory will be a bit iffy and so forth. Plus a special set for valproates: instant old age. You’ll get fat, bald, tired, confused, dry & itchy skin, uninterested in sex, unable to hold your liquor, lose your teeth, and whatever you don’t puke will give you heartburn and/or the runs. Fortunately these side effects are both dosage-dependent (the more valproic acid you take the more likely it is you’ll get them and/or the worse they’ll be) and most, like the nausea and other GI problems, are usually temporary. Unfortunately two side effects people complain about the most - weight gain and hair loss - tend to stick around, as does the occasional tremor and urge to yell at kids to get off of your lawn. At least you can take antacids like Maalox to deal with the GI problems. You cannot take Pepto-Bismal and valproic acid, as its active ingredient is related to aspirin, and aspirin and valproates is a big no-no. Sometimes a really big no-no. The same goes for Alka-Seltzer.

6.2  Not So Common Side Effects

Incontinence3, acne4, lack of menstrual periods and other embarrassing female complaints, and instead of thinning your hair can change texture and/or color.
Valproates are almost as bad as Lamictal (lamotrigine) when it comes to serious rashes. Like lamotrigine the likelihood of a serious, potentially life-threatening rash increases with your dosage. Unlike Lamictal it’s not so freaking random, especially when it comes to being exposed to things you’ve been using prior to taking valproic acid, like laundry detergent or hand lotion. It’s still a good idea to look at the Lamictal page on SJS.

6.3  Freaky Rare Side Effects


Not all that much. All the warnings, precautions, and listings in the PI sheet for rare adverse effects are from Depakene, and not the fake Depakene PI sheets with Depakote’s side effects either. The only semi-wacky event I could find that is peculiar to Stavzor involved an overdose: Acute overdose of enteric-coated valproic acid and olanzapine: unusual presentation and delayed toxicity. That’s it. Unless you’ve got an account with access to everything don’t bother, as there’s no abstract.

Depakene (valproic acid)

There are a few, although for a med that is as old as I am5 I’d expect a hell of a lot more. Most of the really freaky ones, like Fanconi syndrome (constant peeing), onychomadesis (your finger and toe nails fall off and don’t grow back), and gingival overgrowth happen to children. Or if an overdose is taken, and weird things like imitation brain death can happen.

7.  Interesting Stuff Your Doctor Probably Won’t Tell You about Stavzor (valproic acid) Delayed Release Capsules

I haven’t found anything interesting about Stavzor, other than it’s so under the radar that I wrote about it shortly after its release four years ago and have since completely forgotten its existence. In the first 100 results from a Google search fewer than five are from people who take it or have questions about it. The rest are the usual PDR regurgitations from drugs.com, rxlist.com, etc., press releases, ambulance-chasing lawyers.

7.1  Interesting Stuff about Valproic Acid and Valproates in General

  • No, you’re not taking generic Depakote (divalproex sodium). I don’t care what anyone said, Depakote (valproate semisodium) wasn’t available as a generic until 2008, or about when Stavzor was approved. Notice how Depakote has not one, but two generic names that are not valproic acid. Valproic acid is an ingredient of Depakote.
  • Valproic acid interacts with aspirin. Aspirin prevents you from metabolizing valproates properly, so you’re better off with Aleve (naproxen sodium) or Tylenol (acetaminophen). Ibuprofen is OK, but only if you’re taking no more than 400mg a day. While there is no documented interaction, and , I’d be too freaking paranoid to take Tylenol and a valproate at the same time for more than a couple of days.
  • Valproates can sap your body of vitamin D, folic acid, and maybe even calcium. So ask your doctor about tests for vitamin D and calcium levels and supplements. You should probably take 400–1,000mcg of folic acid in any event, but no more than that, otherwise it might interfere with how well valproic acid works. That folic acid may help you feel a lot less lethargic.
  • Bipolar women are able to tolerate more valproate than epileptic women, while epileptic men can tolerate more valproate than bipolar men.
  • Your doctor had better damn well be telling you about the regular blood work you need, to check your valproate levels and to make sure your liver is functioning normally.

8.  Stavzor (valproic acid) Delayed Release Capsules Dosage and How to Take Stavzor (valproic acid) Delayed Release Capsules

8.1  Bipolar Mania

Noven’s recommendations:

The recommended initial dose is 750 mg daily in divided doses. The dose should be increased as rapidly as possible to achieve the lowest therapeutic dose which produces the desired clinical effect or the desired range of plasma concentrations. In placebo-controlled clinical trials of acute mania, patients were dosed to a clinical response with a trough plasma concentration between 50 and 125 mcg/mL. Maximum concentrations were generally achieved within 14 days. The maximum recommended dosage is 60 mg/kg/day. the Stavzor PI sheet

As usual, we disagree. Not with the “the lowest therapeutic dose which produces the desired clinical effect,” as that is the only sane target dosage and we applaud Noven and Abbott (as the wording for Stavzor’s bipolar dosage and administration is nearly a word-for-word copy from the Depakote PI sheet) for recognizing that. Of course they had to ruin it with “or the desired range of plasma concentrations [of] 50 and 125 mcg/mL.”

If you’re so bouncing-off-the-ceiling manic that someone else is reading this page, why the hell aren’t you on Zyprexa or some other antipsychotic for now? In our opinion such a rapid titration is best left for someone who needs to calm the hell down right the hell now! and, for whatever reason, can’t take an antipsychotic. Which is probably why you’re taking Stavzor, right?

Our suggestion if you aren’t bouncing-off-the-ceiling-manic is starting out at 250–500mg a day (one 125mg or 250mg capsule twice a day) and increasing the dosage by 125–250mg a day every three to four days. While taking valproic acid, even the delayed-release flavor, three times a day would be best, we realize what a pricey pain in the ass that would be. Again, Noven demonstrates they know what they’re doing; this time by recognizing you can do only so much with a valproate and that once-a-day dosing is probably a pipe dream.

8.2  Migraine

Noven’s recommendations:

The recommended starting dose is 250 mg twice daily. Some patients may benefit from doses up to 1000 mg/day. In clinical trials, there was no evidence that higher doses led to greater efficacy. the Stavzor PI sheet

We can’t find anything wrong with that. If you’re more comfortable starting at 250mg a day total, taking two 125mg capsules, that’s good.

8.3  Epilepsy

Noven’s recommendations from the PI sheet are incredibly complicated, and take into account:

  • seizure type
  • is this the first AED you’ve taken
  • other medications you’re taking
    • if you plan to keep taking them or stop taking them
  • your weight
  • your gender

Our suggestion assumes that Stavzor is the med you and your doctor agree is the best one. The real question now is - are your seizures happening too often for you to deal with? If so, then you and your doctor should plan a titration schedule (how much to increase the dosage every however many days) to get you taking as much Stavzor/Depakene/valproic acid as quickly as possible until your seizures are under control. If your seizures are infrequent-to-more-or-less-under-control, then you and your doctor can consider a titration schedule with a much more gradual increase in the dosage, so the side effects won’t be so bad.

9.  How Long Stavzor (valproic acid delayed release) & Depakene (valproic acid) Take to Work

9.1  Bipolar Disorder

Stavzor (valproic acid delayed release)

I honestly don’t know. There just aren’t enough data on it.

Depakene (valproic acid)

Will stomp out mania anywhere from a few days to a couple of weeks, depending on how quickly you take how much. Take enough soon enough and valproic acid is almost as effective in calming you the hell down as an antipsychotic. When it comes to bipolar depression it’s anywhere from a month to never. Stavzor is approved to treat bipolar mania, and the FDA got this one right.

9.2  Epilepsy

Both Stavzor (valproic acid delayed release) and Depakene (valproic acid) should work as well as they can for you in about two weeks.

9.3  Migraines

There aren’t a lot of data for either Stavzor or generic valproic acid. Hell, there isn’t even a lot of data for Depakote and migraines. Most of the research is about sodium valproate, especially using the intravenous form (as Depacon - which is the only way you can get it in the US) for emergency room treatment of migraines.
Plus there’s the whole issue of defining efficacy when it comes to migraines, which is a 50% reduction in attacks and 50% reduction in severity. There is so much statistical wriggle room in what should be a very simple definition there’s a reason why I like to gather as much anecdotal evidence as possible, which isn’t much.

10.  How to Stop Taking Stavzor (valproic acid delayed release) and Depakene (valproic acid)

Slowly. Unlike many meds where ideally you’d discontinue as a mirror image of your titration - e.g. if you began taking Stavzor at 250mg a day and increased by 250mg a day every week you’d discontinue by 250mg a day every week until you weren’t taking it any more. As migraineurs, the bipolar who were already taking something and had valproic acid added to their cocktail, and people taking valproic acid for various off-label uses are the only ones who were likely to have had a gentle titration, those groups are the only people for whom the standard method of decrease-as-you-increased is going to work.

As neither Noven nor Abbott before them supplied discontinuation instructions other than “be freaking careful” our suggestion to talk to your doctor about is to reduce your dosage by 250–500mg a day every five to seven days. Based on the half-life of 16 hours you could make that three days, but with the PK being so non-linear combined with it doing weird shit like the tissue binding not being affected by weight above a certain point6, five to seven days is just safer. 7

11.  Stavzor (valproic acid delayed release) and Depakene (valproic acid) Half-Life & Average Time to Clear Out of Your System

Half-life: 9 to 16 hours, plasma clearance: two to three days.

12.  Days to Reach a Steady State

Usually two to three days.

13.  Shelf life

3 years.

14.  How Stavzor (valproic acid delayed release) and Depakene (valproic acid) Work

Originally they thought that valproates increased the amount of GABA you had throughout your brain by inhibiting how it was broken down (much like how an MAOI works) as well as encouraging your brain to produce more, but little else. Current research shows that valproates do that as well as inhibit activity along the sodium and calcium ion channels like many AEDs. They may affect glutamate and/or NMDA as well.


I’ll say one thing for Noven Therapeutics, at least they did some new clinical trials for the approvals, with new side effect (adverse reaction) data. If you look at the Depakene PI sheet you’ll notice how everything is for Depakote, a drug approved years after Depakene was approved, and with a far less harsh side effect profile. I’d really like to know how Abbott got away with that. I had to dig up a 1999 copy of the PDR to get side effects specific to Depakene. On some of the few Stavzor-specific studies I could find, the epileptic said Stavzor’s side effects suck far, far less than seizures, including hair loss and getting fat.

They lowered the minimum therapeutic blood plasma level for the bipolar from 85 to 50 - which is the same minimum effective level as epilepsy. There’s a huge reason as to why the side effects can be a lot less harsh than Depakene and Depakote. You won’t necessarily take 40% less Stavzor than Depakote, but you may not need to take as much to make your doctor happy if you symptoms are under control.

In addition to getting their flavor of valproic acid approved for everything it was being prescribed off-label for in any event, which might be used as a kind of retroactive ass-covering for insurance companies and HMOs who forced everyone to take generic valproic acid instead of the Depakote ER their doctors prescribed, Noven’s big selling point for Stavzor is…the pill won’t choke a horse like Depakote. That and the gastrointestinal side effects are honestly more like Depakote ER instead of the generic valproic acid some people wound up getting in place of the Depakote ER their doctors prescribed them8. Patient-compliance is actually a big deal, so what they did is good. Although I think they need to change the color of their capsules. Those things look like vitamins (think D and E) and fish oil supplements. The only thing that distinguishes them from something you’d buy at Ye Oldde Supplemintt Shoppe is the barely-readable imprint. While I think taking vitamin E is usually a bad idea, vitamin D and omega-3 fish oil supplements are usually good ideas for the mentally interesting. It’s just too damn easy to take too much of one and too little of another when your meds look too much like your supplements.

Shirts to swipe right from
Crazymeds’ Clothes Line.
See more ways to let my
AEDs express your feelings
at Straitjacket T-shirts.Shirts, hoodies & more.
Team Bipolar shirts at Straitjacket T-shirts
Team Bipolar
Breakfast of Champions shirts at Straitjacket T-shirts
Breakfast of Champions
Fuck Epilepsy shirts at Straitjacket T-shirts
Fuck Epilepsy
The Depakote Made Me Eat It shirts at Straitjacket T-shirts
The Depakote Made Me Eat It

Don’t worry about actually buying one. Windows shop and share the designs you’d like to buy. Do you have something better to do right now?

16.  Stavzor Ratings, Reviews, & Other Sites of Interest

16.1  Rate Stavzor

Give your overall impression of Stavzor on a scale of 0 to 5.

Get all critical about Stavzor

2 stars Rating 1.8 out of 5 from 6 criticisms.
Vote Distribution: 2 – 1 – 1 – 1 – 0 – 1

16.2  Rate this article

If you’re still feeling judgmental as well as just mental9, please boost or destroy my self-confidence by honestly (and anonymously) rating this article on a scale of 0 to 5. The more value-judgments the better, even if you can criticize my work only once.

Get all judgmental about the Stavzor (valproic acid) Synopsis

2.5 stars Rates 2.4 out of 5 from 7 value judgments.
Vote Distribution: 3 – 0 – 0 – 0 – 3 – 1

Stick to your AED-based treatment plan. Buttons and magnets, 2.25″ $4 & 3.5″ $4.50 the each
Team Epilepsy buttons at Straitjacket T-shirts
Team Epilepsy
Captain Migraine buttons at Straitjacket T-shirts
Captain Migraine
Team Bipolar magnets at Straitjacket T-shirts
Team Bipolar
Medicated For Your Protection buttons at Straitjacket T-shirts
Medicated For Your Protection

Pages and Forum Topics Google Thinks are Relevant to Your Mental Health

16.3  Full US PI sheet, Global SPCs & PILs, Other Consumer Review & Rating Sites, check for drug-drug interactions

Drugs.com’s drug-drug and drug-food interaction checker

It’s always a good idea to check for drug-drug interactions yourself. Just because most people in the crazy meds business know about really important interactions (e.g. MAOIs and a lot of stuff, warfarin and everything on the planet) doesn’t mean the person who prescribed your meds told you about them, or the pharmacist has all the meds you take at their fingertips like they’re supposed to. Or they have the time to do their jobs properly when not dealing with complete idiots or playing Angry Farmers on the Faecesbooks.

These will stick around longer than AED side effects. More ways to be stuck-up at Straitjacket T-shirts. All stickers only $5
Vaccines Cause Immunity stickers at Straitjacket T-shirts
Vaccines Cause Immunity
Epilepsy Sucks! stickers at Straitjacket T-shirts
Epilepsy Sucks!
Mental Illness is NOT Contagious stickers at Straitjacket T-shirts
Mental Illness is NOT Contagious
Fuck Epilepsy bumper stickers at Straitjacket T-shirts
Fuck Epilepsy

16.4  Discussion board

If you have any questions not answered here, please see the Crazymeds Stavzor discussion board.

Keep Crazymeds on the air.
Donate some spare electronic currency
you have floating around The Cloud

17.  References

  1. Stavzor (valproic acid) Full US Prescribing Information

Stahl’s Essential Psychopharmacology: Neuroscientific Basis and Practical Applications (Essential Psychopharmacology Series) Third edition by Stephen M. Stahl © 2008 Published by Cambridge University Press

The Prescriber’s Guide (Essential Psychopharmacology Series) Third edition by Stephen Stahl © 2009 Published by Cambridge University Press.

Physicians’ Desk Reference Editions 53, 56, & 64 © 1999, 2002, & 2010

Instant Psychopharmacology 2nd Edition Ronald J. Diamond MD © 2002. Published by W.W. Norton

Primer of Drug Action 12th edition by Robert M. Julien Ph.D, Claire D. Advokat, Joseph Comaty © 2011 Published by Worth Publishers.

Essential Neuropharmacology: The Prescriber’s Guide Stephen D. Silberstein, Michael J. Marmura © 2010

Evidence-based Psychopharmacology Dan Stein, Bernard Lerer, Stephen Stahl © 2005 Published by Cambridge University Press.

Pharmacotherapy for Mood, Anxiety, and Cognitive Disorders Stuart A. Montgomery, Halbreich Uriel © 2000

Mosby’s Drug Consult 2007 (Generic Prescription Physician’s Reference Book Series) © 2007

Antiepileptic Drugs René H. Levy, Richard H. Mattson, Brian S. Meldrum, Emilio Perucca © 2003

A 6-month prospective study on efficacy safety and QOL profiles of extended-release formulation of valproate in patients with epilepsy

Short-term efficacy and safety of valproate sustained-release formulation in newly diagnosed partial epilepsy VIPe-study. A multicenter observational open-label study

1 The term "branded generic" has three meanings:
1) A generic drug produced by a generics manufacturer that is a wholly-owned subsidiary of the company that makes the branded version. E.g. Greenstone Pharmaceuticals makes gabapentin, and they are owned by Pfizer, who also own Parke-Davis, the makers of Neurontin.
2) A branded generic is also a generic drug given a 'brand' name by the manufacturer (e.g. Teva's Budeprion), but otherwise has the same active ingredient as the original branded version (Wellbutrin).
3) A branded generic is also a generic drug given a 'brand' name by the manufacturer (e.g. Sanofi-Aventis' Aplenzin, which is bupropion hydrobromide) and uses a salt of the active ingredient that is different from the original branded version and other generics (Wellbutrin, Budeprion and all the others are bupropion hydrochloride). We aren't sure if that really makes a difference or not. The FDA says they're the same thing. As usual, the data are contradictory, but most evidence indicates that the FDA is right and the differences are negligible.
For our purposes a "branded generic name" refers to the second and third definitions.

2 The vast majority of liver problems show up in the first 6 to 12 months of use, especially in the bipolar, as we usually get the most aggressive titration schedules (in English: the highest dosages the fastest) and our livers are often fucked-up to start with thanks to mania-inspired hepatitis, cirrhosis, and other problems. For most people an annual liver function test is more than enough. For anyone who takes a high dosage of a [[Meds/valproate]], smokes, takes other medications (regardless of what they treat) that induce CYP or UGT enzymes, drinks alcohol, or eats a lot of charbroiled meat (I'm not joking), more than one liver function panel and an annual complete blood count would be a good idea.

3 Both kinds. What did I tell you about getting old?

4 So you can feel young again, right? Or just be old with even shittier skin.

5 OK, I'm not that old. Valproic acid was approved as an AED 50 years ago. The substance itself has been around since the late 19th century.

6 In English…uh, well, you know how they like to base the dosage on how much you weigh, because it has to do with how well the drug sticks to your innards? No? Then I can't do much more than that. Sorry.

7 If you've been taking valproic acid, or any drug, for years and have been adjusting the dosages up and down - as is often the case with AEDs - a perfect mirror-image taper is obviously not going to work.

8 It didn't happen to me or anyone I know. I have read quite a few accounts of people getting "generic Depakote" in 2003-2006. They had all sorts of GI problems that were way out of proportion to those listed in the PI sheet and to the anecdotal evidence I've collected regarding Depakote ER. Big Pharma, HMOs and the health insurance cartels have gotten away with, or have been barely punished for much worse, but this is so blatant that even the National Institute of Health's Daily Med website has Depakene's prescribing information where the clinical trials and adverse reactions are from Depakote, a drug approved decades after Depakene was approved and for which valproic acid is an ingredient, along with sodium valproate.

9 Thank you! I'll be here all weak. Be sure to tip your content provider. And don't try the veal, it's cruelicious!

If you have any questions not answered here, please see the Crazymeds Stavzor discussion board. We welcome criticisms of the articles, notifications of bad links, site problems, consumer experiences with medications, etc. I’m not always able to write back. Hence I never answer questions about meds via e-mail that are answered by this or other articles. Especially if they have been repeatedly asked on the forum. That’s why we write these damn things. Questions about which meds are best for your condition should also be asked on the forum; because this is a free site, so the price of admission is making things easier for somebody else searching for the same answer. We don’t deal with children on the forum or in private because after doing this for ten years I don’t have the emotional stamina to deal with kids who have brain cooties. How to contact Crazymeds. — Jerod Poore, CME, Publisher Crazymeds (crazymeds.net)

Last modified on Monday, 04 May, 2015 at 14:46:16 by JerodPoorePage Author Date created
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with Microdata:<span itemprop='citation'> <a href="http://scholar.google.com/citations?user=5rkux7sAAAAJ&hl=en&oi=sra">Poore, Jerod</a>. <a href='https://crazymeds.net/pmwiki/pmwiki.php/Meds/Stavzor'>"Stavzor (valproic acid): a Review for the Educated Consumer."</a>. <a href="https://crazymeds.net/pmwiki/pmwiki.php/Main/HomePage"> <em>Crazymeds (crazymeds.net)</em></a>. ().</span>

Stavzor, and all other drug names on this page and used throughout the site, are a trademark of someone else. Stavzor’s PI Sheet will probably have the name of the manufacturer and trademark owner (they’re not always the same company) at or near the very bottom. Or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing. It may of changed hands by the time you finished reading this article.

Page design and explanatory material by Jerod Poore, copyright © 2003 - 2015. All rights reserved.
Keep up with Crazymeds and and/or my slow descent into irreparable madness boring life. Pick your preferred social media target(s):

Almost all of the material on this site is by Jerod Poore and is copyright © 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, and 2015 Jerod Poore. Except, of course, the PI sheets - those are the property of the drug companies who developed the drugs the sheets are about - and any documents that are written by other people which may be posted to this site will remain the property of the original authors. You cannot reproduce this page or any other material on this site outside of the boundaries of fair use copying without the express permission of the copyright holder. That’s usually me, so just ask first. That means if want to print out a few pages to take to your doctor, therapist, counselor, support group, non-understanding family members or something like that - then that’s OK to just do. Go for it! Please. As long as you include this copyright notice and something along the lines of following disclaimer, I’m usually cool with it.

All rights reserved. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. If you still have questions about a medication or condition that were not answered on any of the pages you read, please ask them on Crazy Talk: the Crazymeds Forum.
The information on Crazymeds pertains to and is intended for adults. While some information about children and adolescents is occasionally presented (e.g. US FDA approvals), pediatric-specific data such as dosages, side effects, off-label applications, etc. are rarely included in the articles on drugs or discussed on the forum. If you are looking for information regarding meds for children you’ll have to go somewhere else. Plus we are big pottymouths and talk about S-E-X a lot.
Know your sources!
Nobody on this site is a doctor, a therapist, or a pharmacist. We don’t portray them either here or on TV. Only doctors can diagnose and treat an illness. While it’s not as bad as it used to be, some doctors still get pissed off by patients who know too much about medications, so tread lightly when and where appropriate. Diagnosing yourself from a website is like defending yourself in court, you suddenly have a fool for a doctor. Don’t be a cyberchondriac, thinking you have every disease you see a website about, or that you’ll get every side effect from every medication1. Self-prescribing is as dangerous as buying meds from fraudulent online pharmacies that promise you medications without prescriptions.
All information on this site has been obtained from the medications’ product information / summary of product characteristic (PI/SPC) sheets and/or medication guides - which is all you get from sites like WebMD, RxList, NAMBLA NAMI, etc., the sources that are referenced throughout the site, our personal experience and the experiences family, friends, and what people have reported on various reputable sites all over teh intergoogles. As such the information presented here is not intended as a substitute for real medical advice from your real doctor, just a compliment to it. You should never, ever, replace what a real doctor tells you with something from a website on the Internet. The farthest you should ever take it is getting a second opinion from another real doctor. Educate yourself - always read the PI/SPC sheet or medication guide/patient information leaflet (PIL) that comes with your medications and never ever throw them away. OK, you can throw away duplicate copies, but keep at least one, as that’s your proof of purchase of having taken a med in case a doctor doubts your medical history. Plus they take up less space than a bottle, although keeping one inside of a pill bottle is even better.
Crazymeds is not responsible for the content of sites we provide links to. We like them, or they’re paid advertisements, or they’re something else we think you should read to help you make an informed decision about a particular med. Sometimes they’re more than one of those things. But what’s on those sites is their business, not ours.
Very little information about visitors to this site is collected or saved. From time to time I look at search terms used and which pages they bring up in an effort to make the information I present more relevant. And the country of origin, just because I’m geeky like that. That’s about it. Depending on how you feel about Schrodinger, our privacy policy should either assuage or exacerbate your paranoia.
Crazymeds is optimized for ridiculously large screens and browsers that don’t block ads. I use Firefox and Chrome, running under Windows 72. On a computer that sits on top of my desk. With a 23 inch monitor. Hey, at least you can make the text larger or smaller by clicking on the + or - buttons in the upper right hand corner. If you have Java enabled. Like 99% of the websites on the planet, Crazymeds is hosted on domain running an open source operating system with a variety of open source applications, including the software used to display what you’ve been reading. As such Crazymeds is not responsible for whatever weird shit your browser does or does not do when you read this site3.
No neurologists, psychiatrists, therapists or pharmacists were harmed in the production of this website. Use only as directed. Void where prohibited. Contains nuts. Certain restrictions may apply. All data are subject to availability. Not available on all mobile devices, in the 12 Galaxies Guiltied to a Zegnatronic Rocket Society, or in all dimensions of reality. Hail Xenu!

‘Everything is true, nothing is permitted.’ - Jerod Poore

1 While there are plenty of books to help you with hypochondria, for some reason there’s not much in the way of websites. Then again, staying off of the Internet is a large part of curing/managing the disorder.

2 Remember kids, Microsloth operating systems are like TOS Star Trek movies with in that every other one sucks way, way more. With TOS Star Trek movies you don’t want to bother watching the odd-numbered ones. With Microsloth OS you don’t want to buy and install the even-numbered ones. Anyone who remembers ME and Vista knows what I mean.

3 Have I mentioned how open source operating systems for commercial applications is one of the dumbest ideas in the history of dumb ideas?* I don’t even need my big-ass rant any more. Heartbleed has made my case for me. And that’s just the one that got all the media attention. The very nature of an open source operating system makes security as much of an illusion as anonymity on teh Intergoogles. Before you flip out too much: the domain Crazymeds is hosted on uses a version of SSL that is not affected by the Heartbleed bug. That’s one of the many reasons why I pay a lot of money and keep this site on Lunarpages.

* Yes, I know I’m using open source browsers. I also test the site using the now-defunct IE and Safari browsers. Their popularity - and superiority - killed IE and Safari, so that’s why I rely on the open source browsers. It’s like brand vs. generic meds. Sometimes the generic is better than the brand.

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