plus assorted interesting stuff about Zoloft (sertraline) your doctor won’t tell you
Anyone who uses this page, or any other short list of pros and cons, as the only sources of information in deciding which med to take for their condition is a complete idiot and/or crazier than they or anyone else suspects. Although far less stupid and/or crazy than those who choose meds based only on side effects or the recommendations of random people on sites like ask.yahoo.com.
- The slight, but noticeable, dopamine action Zoloft has is often enough to get you out of bed and back to work within a couple of days. You might still be depressed for another two-four weeks, but at least you don’t have to lie in bed staring at the ceiling and ruminating on how much your life sucks.
- That also makes weight gain less likely.
- Zoloft has the lowest rate of cardiovascular side effects of any SSRI.
- The slight dopamine action Zoloft has makes it the worst Serotonin-[sorta-]Selective Reuptake Inhibitor to take if bipolar is known or suspected.
- Definitely the worst to have taken if your bipolar diagnosis was a surprise.
- By “the worst” I don’t mean it’s more likely than any other SSRI to trigger mania, that’s the same as all the others. No, by “the worst” I mean you’re more likely to have a dysphoric, smash everything in site, scare the shit out of the kids, have the neighbors call the cops mania instead of a euphoric, max out your credit cards, drive to Vegas and marry a complete stranger mania.
- Then again, it’s difficult to truly gauge “worst.”
- While the dopamine action is in the right place to make you sweaty and nervous (like Wellbutrin), and to exacerbate insomnia, it’s nowhere near the right place to prevent sexual side effects.
Doctors don’t have the time to tell you everything about a drug. Patient information leaflets leave out a lot. Even if the PI sheet covers everything the language is so dense and obtuse that the good stuff is often lost in information overload. Most meds have something interesting about them.1
Interesting Stuff Your Doctor Probably won’t Tell You about Zoloft (sertraline)
- Zoloft has some interesting pharmacokinetics
- If you take the tablets with food you’ll get a 25% increase in Zoloft’s peak plasma - the most you’d have in your blood - and it will happen faster, dropping from 8 hours to 5.5.
- If you take the oral concentrate with food you won’t get any more out of it, but it will take longer to reach that peak amount, from 5.9 to 7 hours.
- Increased and/or delayed peak plasma when taking meds with food happens all the time. But these numbers only make sense if the volunteers were professional lab rats.
- Zoloft is one of the few modern antidepressants (not a TCA or MAOI) where taking a month’s worth all at once could possibly kill you.
- You’d need a prescription for 150–200mg a day, and the odds are still 99-to-1 against you dying
- unless you take other stuff with it - then who knows what the odds are - but it’s still a greater than zero chance.
- You’d need a prescription for 150–200mg a day, and the odds are still 99-to-1 against you dying
Most drugs are known for something. Whenever Viagra or Cialis are mentioned what do you think of first? How effective either one is for erectile dysfunction? The pros and cons of each? Viagra’s weird side effect of cyanopsia (where everything you see is tinted blue)? Or that a hard-on can last over four hours, and that if it does you’re supposed to call Dr. Buzzkill about it to see if you may need a surgical happy ending?2
Crazy meds are no different. Most of them are notorious for some reason. Lamictal is best known for “The Rash” (or “The Lamictal Rash”), but it’s also the best drug on the planet to treat Bipolar II. Topamax is also known as Dopamax and Stupamax, and here at Crazymeds we coined the term “supermodel drugs” to describe Topamax and Zonegran, because they can make you skinny and stupid. Yet Topamax is also a Godsend for a lot of people with migraines and/or various forms of epilepsy, and is the first thing a lot of neurologists will prescribe.
Drugs can sometimes have lesser-known traits and effects that make them unique, such as Keppra’s ability to stop mania immediately as if it were an antipsychotic as well as killing brain cancer. Some are good, some are bad, some are just weird. Some might be helpful for you to know about in order to make the best use a med, or to help it suck less. Others are meaningful only to pharmacology geeks.
What Zoloft (sertraline) is Best Known for
- The ad campaign featuring rolling blobs.
- Letting people know they bipolar with a nasty dysphoric mania instead of the stereotypical happy-happy joy-joy euphoric mania.
- Always remember: Your mileage may vary (YMMV).
- You can get that surprise diagnosis in the form of a dysphoric mania with other antidepressants, and
- Zoloft can trigger euphoric mania,
- but the odds are zoloft + bipolar - mood stabilizer = dysphoric mania.
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1 Interesting to me at any rate.
2 Fun facts: The cause of that never-ending boner (priapism) is often a blood clot, which can work its way loose, make its way to your brain or heart, and kill you. So it's not so much about the inconvenience of a tent pole that can never be unpitched, it's about a potentially fatal side effect of ED drugs that they never say is POTENTIALLY FATAL in the TV ads. Viagra and Cialis are as, if not more likely to kill you than an antidepressant, but is Tom Cruise jumping up and down on a couch screaming about that? Maybe Scientology alone couldn't help him with that issue. As for the surgery that might be required, see Erectile function and dysfunction following low flow priapism: a comparison of distal and proximal shunts for the gory details, with pictures that will make you lose a few inches.
If you have any questions not answered here, please see the Crazymeds Zoloft discussion board. We welcome criticisms of the articles, notifications of bad links, site problems, consumer experiences with medications, etc. I’m not always able to write back. Hence I never answer questions about meds via e-mail that are answered by this or other articles. Especially if they have been repeatedly asked on the forum. That’s why we write these damn things. Questions about which meds are best for your condition should also be asked on the forum; because this is a free site, so the price of admission is making things easier for somebody else searching for the same answer. We don’t deal with children on the forum or in private because after doing this for ten years I don’t have the emotional stamina to deal with kids who have brain cooties. How to contact Crazymeds. — Jerod Poore, CME, Publisher Crazymeds (crazymeds.net)
|Last modified on Sunday, 10 May, 2015 at 17:17:43 by JerodPoore||Page Author Jerod Poore||Date created|
|“Zoloft (sertraline): a Review for the Educated Consumer.” by Jerod Poore is copyright © Jerod Poore||Published online 2011/04/06|
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Zoloft, and all other drug names on this page and used throughout the site, are a trademark of someone else. Zoloft’s PI Sheet will probably have the name of the manufacturer and trademark owner (they’re not always the same company) at or near the very bottom. Or ask Google who the owner is. The way pharmaceutical companies buy each other and swap products like Monopoly™ real estate, the ownership of the trademark may have changed without my noticing. It may of changed hands by the time you finished reading this article.
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Almost all of the material on this site is by Jerod Poore and is copyright © 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, and 2015 Jerod Poore. Except, of course, the PI sheets - those are the property of the drug companies who developed the drugs the sheets are about - and any documents that are written by other people which may be posted to this site will remain the property of the original authors. You cannot reproduce this page or any other material on this site outside of the boundaries of fair use copying without the express permission of the copyright holder. That’s usually me, so just ask first. That means if want to print out a few pages to take to your doctor, therapist, counselor, support group, non-understanding family members or something like that - then that’s OK to just do. Go for it! Please. As long as you include this copyright notice and something along the lines of following disclaimer, I’m usually cool with it.
All rights reserved. No warranty is expressed or implied in this information. Consult one or more doctors and/or pharmacists before taking, or changing how you take any neurological and/or psychiatric medication. Your mileage may vary. What happened to us won’t necessarily happen to you. If you still have questions about a medication or condition that were not answered on any of the pages you read, please ask them on Crazy Talk: the Crazymeds Forum.
The information on Crazymeds pertains to and is intended for adults. While some information about children and adolescents is occasionally presented (e.g. US FDA approvals), pediatric-specific data such as dosages, side effects, off-label applications, etc. are rarely included in the articles on drugs or discussed on the forum. If you are looking for information regarding meds for children you’ll have to go somewhere else. Plus we are big pottymouths and talk about S-E-X a lot.
Know your sources!
Nobody on this site is a doctor, a therapist, or a pharmacist. We don’t portray them either here or on TV. Only doctors can diagnose and treat an illness. While it’s not as bad as it used to be, some doctors still get pissed off by patients who know too much about medications, so tread lightly when and where appropriate. Diagnosing yourself from a website is like defending yourself in court, you suddenly have a fool for a doctor. Don’t be a cyberchondriac, thinking you have every disease you see a website about, or that you’ll get every side effect from every medication1. Self-prescribing is as dangerous as buying meds from fraudulent online pharmacies that promise you medications without prescriptions.
All information on this site has been obtained from the medications’ product information / summary of product characteristic (PI/SPC) sheets and/or medication guides - which is all you get from sites like WebMD, RxList,
NAMBLA NAMI, etc., the sources that are referenced throughout the site, our personal experience and the experiences family, friends, and what people have reported on various reputable sites all over teh intergoogles. As such the information presented here is not intended as a substitute for real medical advice from your real doctor, just a compliment to it. You should never, ever, replace what a real doctor tells you with something from a website on the Internet. The farthest you should ever take it is getting a second opinion from another real doctor. Educate yourself - always read the PI/SPC sheet or medication guide/patient information leaflet (PIL) that comes with your medications and never ever throw them away. OK, you can throw away duplicate copies, but keep at least one, as that’s your proof of purchase of having taken a med in case a doctor doubts your medical history. Plus they take up less space than a bottle, although keeping one inside of a pill bottle is even better.
Crazymeds is not responsible for the content of sites we provide links to. We like them, or they’re paid advertisements, or they’re something else we think you should read to help you make an informed decision about a particular med. Sometimes they’re more than one of those things. But what’s on those sites is their business, not ours.
Crazymeds is optimized for ridiculously large screens and browsers that don’t block ads. I use Firefox and Chrome, running under Windows 72. On a computer that sits on top of my desk. With a 23 inch monitor. Hey, at least you can make the text larger or smaller by clicking on the + or - buttons in the upper right hand corner. If you have Java enabled. Like 99% of the websites on the planet, Crazymeds is hosted on domain running an open source operating system with a variety of open source applications, including the software used to display what you’ve been reading. As such Crazymeds is not responsible for whatever weird shit your browser does or does not do when you read this site3.
No neurologists, psychiatrists, therapists or pharmacists were harmed in the production of this website. Use only as directed. Void where prohibited. Contains nuts. Certain restrictions may apply. All data are subject to availability. Not available on all mobile devices, in the 12 Galaxies Guiltied to a Zegnatronic Rocket Society, or in all dimensions of reality. Hail Xenu!
‘Everything is true, nothing is permitted.’ - Jerod Poore
1 While there are plenty of books to help you with hypochondria, for some reason there’s not much in the way of websites. Then again, staying off of the Internet is a large part of curing/managing the disorder.
2 Remember kids, Microsloth operating systems are like TOS Star Trek movies with in that every other one sucks way, way more. With TOS Star Trek movies you don’t want to bother watching the odd-numbered ones. With Microsloth OS you don’t want to buy and install the even-numbered ones. Anyone who remembers ME and Vista knows what I mean.
3 Have I mentioned how open source operating systems for commercial applications is one of the dumbest ideas in the history of dumb ideas?* I don’t even need my big-ass rant any more. Heartbleed has made my case for me. And that’s just the one that got all the media attention. The very nature of an open source operating system makes security as much of an illusion as anonymity on teh Intergoogles. Before you flip out too much: the domain Crazymeds is hosted on uses a version of SSL that is not affected by the Heartbleed bug. That’s one of the many reasons why I pay a lot of money and keep this site on Lunarpages.
* Yes, I know I’m using open source browsers. I also test the site using the now-defunct IE and Safari browsers. Their popularity - and superiority - killed IE and Safari, so that’s why I rely on the open source browsers. It’s like brand vs. generic meds. Sometimes the generic is better than the brand.